TARKA® (trandolapril/verapamil hydrochloride ER tablets) Use and Important Safety Information1


  • TARKA is a prescription medicine used to treat high blood pressure.
  • TARKA combines two blood pressure medicines (trandolapril and verapamil) into one pill. TARKA is not to be used for initial treatment of high blood pressure.


  • TARKA should not be taken by women during pregnancy due to the risk of injury and even death to the developing fetus. If you become pregnant, tell your doctor right away and follow the instructions you receive about taking TARKA.
  • Do not take TARKA if you are a nursing mother.
  • Some patients taking TARKA may experience heart problems, including changes in heart rhythm. TARKA should not be taken by people with certain heart conditions or low blood pressure. If you are a diabetic patient, do not take TARKA if you are also taking aliskiren. It is very important that your doctor is aware of all current and past medical conditions, including heart problems, liver, or kidney disease.
  • Do not take TARKA if you are allergic to verapamil or an ACE inhibitor or if you are taking a medicine that is a neprilysin inhibitor (e.g., sacubitril). Do not take TARKA within 36 hours of switching to or from sacubitril/valsartan, a neprilysin inhibitor. Ask your doctor about your medications for more information.
  • Tell your doctor about any allergic reactions to all medications. TARKA may cause serious allergic reactions or a reaction called angioedema which includes swelling of the face, body, lips, tongue, or throat. If this occurs, contact your doctor or seek emergency care right away.
  • TARKA may cause excessive low blood pressure and dizziness, especially in certain types of patients with heart failure or who are salt- or volume-depleted.
  • TARKA can cause liver problems. Notify your doctor immediately if you develop symptoms of jaundice, such as yellow coloring of the skin and eyes, while on TARKA.
  • If you have kidney disease or connective tissue disease, your doctor should do periodic blood tests, as TARKA may decrease your white blood cell count.
  • TARKA can interact with other medicines. Before and while taking TARKA, tell your doctor about all medications that you are taking, including prescription and nonprescription drugs.
  • The most common side effects include first-degree heart block, slow heart rate, bronchitis, chest pain, constipation, cough, diarrhea, dizziness, difficulty breathing, fatigue, increased liver enzymes, nausea, pain (extremities), pain (joints).

This is the most important information you should know about TARKA. For more information, talk to your doctor.

Reference: 1. TARKA [package insert]. North Chicago, IL: AbbVie Inc.