TARKA® (trandolapril/verapamil hydrochloride ER tablets) Use and Important Safety Information1
USE for TARKA
- TARKA is a prescription medicine used to treat high blood pressure.
- TARKA combines two blood pressure medicines (trandolapril and verapamil) into one
pill. TARKA is not to be used for initial treatment of high blood pressure.
IMPORTANT SAFETY INFORMATION for TARKA
- TARKA should not be taken by women during pregnancy due to the risk of
injury and even death to the developing fetus. If you become pregnant, tell your
doctor right away and follow the instructions you receive about taking TARKA.
- Do not take TARKA if you are a nursing mother.
- Some patients taking TARKA may experience heart problems, including changes in
heart rhythm. TARKA should not be taken by people with certain heart conditions or
low blood pressure. If you are a diabetic patient, do not take TARKA if you are also
taking aliskiren. It is very important that your doctor is aware of all current and past
medical conditions, including heart problems, liver, or kidney disease.
- Do not take TARKA if you are allergic to verapamil or an ACE inhibitor or if you are
taking a medicine that is a neprilysin inhibitor (e.g., sacubitril). Do not take TARKA
within 36 hours of switching to or from sacubitril/valsartan, a neprilysin inhibitor. Ask
your doctor about your medications for more information.
- Tell your doctor about any allergic reactions to all medications. TARKA may cause
serious allergic reactions or a reaction called angioedema which includes swelling of
the face, body, lips, tongue, or throat. If this occurs, contact your doctor or seek
emergency care right away.
- TARKA may cause excessive low blood pressure and dizziness, especially in certain
types of patients with heart failure or who are salt- or volume-depleted.
- TARKA can cause liver problems. Notify your doctor immediately if you develop
symptoms of jaundice, such as yellow coloring of the skin and eyes, while on TARKA.
- If you have kidney disease or connective tissue disease, your doctor should do
periodic blood tests, as TARKA may decrease your white blood cell count.
- TARKA can interact with other medicines. Before and while taking TARKA, tell your
doctor about all medications that you are taking, including prescription and
- The most common side effects include first-degree heart block, slow heart rate,
bronchitis, chest pain, constipation, cough, diarrhea, dizziness, difficulty breathing,
fatigue, increased liver enzymes, nausea, pain (extremities), pain (joints).
This is the most important information you should know about TARKA. For more information, talk to your doctor.
Reference: 1. TARKA [package insert]. North Chicago, IL: AbbVie Inc.